Pulmonary epithelial cells
WebIn this study, we report that TNF-alpha stimulates the expression of the FRA-1 protooncogene in human pulmonary epithelial cells using c-Jun, acting via a 12-O-tetradecanoylphorbol-13 acetate response element located at -318. Although TNF-alpha stimulates phosphorylation of c-Jun, the inhibition of JNK activity had no significant effect … WebFeb 15, 2024 · A role of arginase in pulmonary aging and underlying mechanisms are not explored. Our present study shows increased Arg‐II levels in aging lung of female mice, which is detected in bronchial ciliated epithelium, club cells, alveolar type 2 (AT2) pneumocytes, and fibroblasts (but not vascular endothelial and smooth muscle cells).
Pulmonary epithelial cells
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WebCOVID-19 has different clinical stages, and effective therapy depends on the location and extent of the infection. The purpose of this review is to provide a background for understanding the progression of the disease throughout the pulmonary epithelium and discuss therapeutic options. The prime sites for infection that will be contrasted in this … WebAbstract. Idiopathic pulmonary fibrosis (IPF) is characterised by repeated injury to the alveolar epithelium with loss of lung epithelial cells and abnormal tissue repair, resulting in excessive accumulation of fibroblasts and myofibroblasts, deposition of extracellular matrix components and distortion of lung architecture, eventually leading to respiratory failure.
WebJan 8, 2024 · To evaluate the significance of AXL in SARS-CoV-2 infection of pulmonary epithelial cells, we knocked down ACE2, AXL, LDLR, or EGFR (Supplementary information, Fig. S6) in H1299 cells by transfecting the cells with corresponding siRNAs and then infected the cells with the SARS-CoV-2 virus pseudotype (Fig. 5a, b). WebApr 14, 2024 · Distal type BA are predominantly composed of non-ciliated luminal cells, resembling type II pneumocytes, and club cells. They are mostly flat. The basal cell layer is highlighted by basal cell markers, p40, p63 or CK5/6. The luminal cells in distal type BA are more likely to be positive for TTF-1 than in proximal type BA. The etiology of BA is ...
WebJan 7, 2006 · They are multifunctional cells that synthesize and secrete pulmonary surfactant, serve as progenitor cells for type 1 alveolar cells, directionally transport sodium from apical to basolateral cell surfaces to minimize alveolar fluid, and participate in the effector phase of the immune response by producing molecules involved in innate host … WebProvided herein is a method for treating pulmonary fibrosis comprising: administering to a patient in need of treatment a therapeutically effective amount of an anti-CSF3R antibody, wherein the anti-CSF3R antibody is injected into lung tissue of the patient to: performs a function selected from: inhibiting CSF3R-mediated epithelial-mesenchymal transition of …
WebPulmonary alveolar epithelial cells (PAEpiC), comprised of alveolar type I and type II ...
WebWe use both BEAS-2B and primary airway cells as pulmonary epithelial controls. HEL-299, MRC-9, WI-38 these are normal fibroblast cells. Depends on your type of research study. For lung epithelial ... rockingham turf care facebookWebOct 15, 2024 · Pulmonary epithelial cells are widely considered to be the first line of defence in the lung and are responsible for coordinating the innate immune response to injury and subsequent repair. Consequently, epithelial cells communicate with multiple cell types including immune cells and fibroblasts to promote acute inflammation and normal wound … rockingham turf careWebAbstract: BACKGROUND: Pulmonary fibrosis (PF) is one of the main causes of death in patients with paraquat (PQ) poisoning. This study aimed to evaluate the relationship between mitochondrial fission and oxidative stress in PQ-induced epithelial-mesenchymal transition (EMT) and PF. rockingham tuxedo bridal incWebAcceGen provides cryopreserved primary alveolar epithelial cells for the best viability and plating efficiency. Each vial contains >0.5 x 10^6 cells in 1ml volume. AcceGen Human Pulmonary alveolar epithelial cells are characterized by immunofluorescent method with antibodies E-cadherin and ZO-1. Cells are guaranteed for future culture in our ... rockingham trainWebBronchial epithelial cell cultures were obtained by air-liquid interface in 4 smokers. The samples were exposed to increasing concentrations of cigarette smoke (5-20%) and the epithelial mRNA expressions of MUC5AC, IL8 and TNFα were determined. ... Pulmonary Disease, Chronic Obstructive / immunology* other terms for lessons learnedWebApr 14, 2024 · We aimed to investigate whether exosomes (Exo) affected chronic obstructive pulmonary disease (COPD) by influencing ferroptosis of bronchial epithelial cells (BECs) and the mechanisms involved. rockingham trophiesWebFeb 20, 2024 · The pulmonary alveolar epithelium is mainly composed of two types of epithelial cells: alveolar type I (AT1) and type II (AT2) cells. AT2 cells are smaller, cuboidal cells that are best known for their functions in synthesizing and secreting pulmonary surfactant. In addition, AT2 cells serve as alveolar stem cells and can differentiate into … rockingham truck repair