Phorbol dibutyrate
WebPhorbol-12,13-dibutyrat, CAS-Nr. 37558-16-0, Calbiochem. undefined. Synonyms: PDBu, Phorbol-12,13-dibutyrat, CAS-Nr. 37558-16-0, Calbiochem. CAS 37558-16-0. Molecular … WebPKC, a phorbol ester receptor, copurified with specific binding sites of ({sup 3}H)phorbol-12,13,-dibutyrate (({sup 3}H)PDBu). The specific binding of ({sup 3}H)PDBu to intact cells was saturable to a single class of binding sites. The PKC and phorbol ester receptors in N1E-115 cells can be down regulated by prolonged phorbol ester incubation.
Phorbol dibutyrate
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WebThe vasoconstrictive properties of endothelin (ET-1) and the protein kinase C activator, phorbol 12-13 dibutyrate (PDB) were comparatively investigated in isolated rat aorta. ET-1 and PDB induced a slowly developing sustained contraction in endothelium denuded aorta. WebOct 31, 1989 · Elevated levels of diacylglycerol and persistent activation/down-regulation of protein kinase C reduced the binding of phorbol dibutyrate to transformed cells. This phenomenon could be reversed by blocking the glycolytic pathway, thus indicating that neosynthesized diacylglycerol was responsible for persistent activation and down …
WebApr 15, 1997 · Classical protein kinase C (PKC) family members are activated by the binding of various ligands to one of several cysteine-rich domains of the enzyme. The natural agonist, diacylglycerol (DAG), and the natural product superagonist, phorbol dibutyrate (PDB), activate the enzyme to produce wide-ranging physiological effects ... WebPHORBOL-12,13-DIBUTYRATE Add to MyChemicals Chemical Identifiers What is this information? The Chemical Identifier fieldsinclude common identification numbers, the NFPA diamondU.S. Department of Transportation hazard labels, and a general description of the chemical. The information in CAMEO Chemicals comes from a variety of
WebPhorbol esters are specific activators of PKC and, therefore, have been used by several investigators (referenced in Bárány et al., 1992b) to assess the role of PKC-induced phosphorylation in smooth muscle contractility. PDBu is the most commonly used phorbol ester, because it is more potent than the other phorbol derivatives. WebPhorbol 12,13-dibutyrate is a phorbol ester which is one of the constituents of croton oil. As an activator of protein kinase C, it is a weak tumor promoter compared to 12-O …
WebNov 29, 2024 · Phorbol Dibutyrate. In addition, PDBu causes somatic excitability increases, membrane depolarization, and increased input resistance in a concentration-dependent …
WebBackground. Phorbol 12, 13-Dibutyrate (PDBu) is a phorbol ester and a potent activator of protein kinase C (PKC). Frequently used in cancer research, PDBu is widely characterized to promote tumors in a variety of tissue types (1,2). PDBu treatment of cells can lead to … personality tests and psychologyWebPhorbol-12,13-dibutyrate - CAS 37558-16-0 - Calbiochem 524390 Sigma-Aldrich Phorbol-12,13-dibutyrate - CAS 37558-16-0 - Calbiochem Download Zoom Strong irritant for mouse skin, but only moderately active as a tumor promoter. MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents. SDS CoA … standard o-ring sizes parkerhttp://madrasathletics.org/rabbit-muscle-contraction-lab-report personality tests backgroundWeb目的 比较瘢痕疙瘩成纤维细胞(KFb)与正常皮肤成纤维细胞(NFb)在常氧和低氧培养状态下的线粒体功能和能量代谢状态,以探讨瘢痕疙瘩成纤维细胞线粒体功能在瘢痕疙瘩发病中的作用.方法 采用组织块贴壁法原代培养KFb和NFb.常氧和低氧(2％O2)条件下培养KFb与NFb,CCK-8检测细胞增殖情况,分光光度法测定细胞 ... standard origination fee mortgageWebTreatment with carbachol, isoproterenol, or phorbol 12,13-dibutyrate resulted in no significant change. In contrast, heavy chain was phosphorylated to 0.30 mol of phosphate/mol of heavy chain in tracheal smooth muscle cells in culture. This value increased signifi- cantly with ionomycin treatment. In control tissues, personality tests dark triadWebOct 15, 2002 · Phorbol dibutyrate (PDBu) induced the formation of podosome-like structures together with partial disassembly of actin stress fibers in A7r5 smooth muscle cells. … standard or intermediate suvWebOur used phorbol 12, 13-dibutyrate (PDBu) and 1, 2-dioctanoyl-sn-glycerol (DOG), activators of PKC, in this examining. We were interested in dissecting an role(s) from PKC and to clarify the signaling pathways in bladder smooth muscle contraction, especially the potential cross-talk with ROCK and to downstream effectors in regulating myosin ... standard or itemized deduction calculator