WebJan 30, 2024 · We then assessed the effects of two pharmacological FASN inhibitors, C75 and Orlistat. We used C75 and Orlistat concentrations that do not induce significant cell death (supplementary Figure 4A-B) or decrease proliferation (Supplementary figure 4C-D) to avoid non-specific results. Of note, FASN protein levels in APL cells were not reduced by ... WebJul 6, 2012 · Fatty acid synthase (FASN) is overexpressed and hyperactivated in several human carcinomas, including lung cancer. We characterize and compare the anti-cancer effects of the FASN inhibitors C75 and (−)-epigallocatechin-3-gallate (EGCG) in a lung cancer model. We evaluated in vitro the effects of C75 and EGCG on fatty acid …
Mong-Hong Lee - Professor - The University of Texas …
WebDec 12, 2024 · The cells were treated with vehicle, the FASN inhibitor C75 (40 µM), or the MAGL inhibitor JZL184 (10 µM). ( B ) Effect of FASN knockdown upon migration and invasion of FABP5 expressing LNCaP cells. WebTo further establish a role for FASN in the LPS activation of macrophages by LPS, we used the well-characterized FASN inhibitor, C75. As can be seen in Fig. 1B, C75 effectively inhibited the production of the pro-inflammatory cytokines IL1β and TNF-α and the anti-inflammatory cytokine IL10 at all time points tested following LPS stimulation. shrek the halls behind the voice actors
Fatty acid synthase phosphorylation: a novel therapeutic …
WebFASN is the key metabolic enzyme of de novo lipogenesis that has been considered a therapeutic target in various cancer types.37 C75 is an inhibitor of FASN, and acts as a stimulator of carnitine palmitoyltransferase-1 to induce FA oxidation.38 To test whether C75 promotes the antitumor activity of CYH33, CYH33 and C75 alone or in combination ... WebC75 is a synthetic fatty-acid synthase ( FASN) inhibitor; inhibits prostate cancer cells PC3 with an IC50 of 35 μM [1] [2] [3]. C75 is a potent CPT1A activator [5] . IC 50 & Target. IC50: 35 μM (PC3 cell) [1] In Vitro. C75 … WebSeveral fatty acid synthase (FASN) inhibitors, including orlistat, C93, C75, GSK2194069, and GSK837149A, have been evaluated in preclinical testing [118, 119]. These compounds, however, show ... shrek the halls free