Cisplatin a549 xenograft
WebJul 15, 2024 · The cisplatin-resistant A549 cell line (A549/DDP), the parent cell line A549, and 293 cells (JRDUN Biotech. Shanghai, China) were maintained in a humidified atmosphere with 5% CO 2 at 37 °C. WebOct 1, 2024 · A549 human lung carcinoma cells were obtained from the Korean Cell Line Bank (Seoul, Republic of Korea) and cultured in RPMI 1640 medium with 10% …
Cisplatin a549 xenograft
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WebOct 7, 2013 · A Balb/c nude mouse xenograft model using A549 cells was previously established. The mice were randomly divided into normal, mock, Ke, cisplatin (DDP), and co-formulated (Ke + DDP) groups. After 15 days of drug administration, the animals were sacrificed, body weight and tumor volume were recorded, and the tumor-inhibiting rate … WebJan 20, 2024 · Deferoxamine Counteracts Cisplatin Resistance in A549 Lung Adenocarcinoma Cells by Increasing Vulnerability to Glutamine Deprivation-Induced Cell Death . Authors Wen-Jun Liu 1 2 , Peng-Yu Pan 2 , Ye Sun 3 , Jian-Bo Wang 4 , Huan Zhou 2 , Xin Xie 1 , Zhi-Yuan Duan 1 , Han-Yu Dong 2 , Wen-Na Chen 4 , Li-de Zhang 2 , …
Web2 days ago · Complex 11 showed a significant in vivo anticancer effect, revealed by its inhibiting effects on tumor growth in T24 xenograft mice without any renal pathological changes or influence on renal function. ... Complexes 36–40 were tested against lung carcinomas A549 and A549/DDP, cisplatin-insensitive cells, and normal healthy (HL … WebDec 1, 2024 · Cisplatin-based chemotherapy is a common first-line regimen for treating non–small cell lung cancer (NSCLC). However, drug resistance is still a major problem. The purposes of this study were to evaluate whether sclareol can reverse cisplatin resistance and to investigate its possible mechanisms.
WebNov 29, 2024 · Background: Cisplatin plus pemetrexed combination therapy is considered the standard treatment for patients with advanced, non-squamous, non-small-cell lung cancer (NSCLC). However, advanced NSCLC has a 5-year survival rate of below 10%, which is mainly due to therapy resistance. WebJan 12, 2024 · Here, we show that this combination enhances the anti-cancer effect of cisplatin in both in vitro cell lines and in vivo xenograft mouse models of cisplatin-sensitive and -resistant lung, ovarian ...
WebDownload Table The 50 % inhibitory concentration (IC50) of cisplatin in A549 and A549/DDP cells 48 h after drug treatment from publication: RNA interferences targeting the Fanconi anemia/BRCA ...
WebFurthermore, combined treatment with intravenous injections of Lps-pVAX-LKB1 and intraperitoneal injection of low-dose cisplatin into mice bearing experimental A549 lung metastasis demonstrated significant (P<0.01) decrease in … how many people died under mao zedong ruleWebIn the present study, the sequence‑dependent effects of GEM and CDDP were investigated in the NSCLC cell line, A549. Significantly increased rates of inhibition and cell cycle … how can i learn koreanWebMay 28, 2024 · In xenograft models, osimertinib significantly inhibited tumor growth, however, as expected, in 50% of mice drug-resistance developed. A combination of osimertinib with pemetrexed or cisplatin prevented or at … how can i learn japaneseWebFeb 25, 2015 · (A) A549 DDP cells transfected with sCLU shRNA or scramble shRNA were injected subcutaneously into the right flank of nude mice. When tumors reached −100 mm 3 in volume, the mice received daily 200 μl i.p. injections of DDP (4 mg/kg body/wt.,i.p). DDP was administered i.v. once every 3 days. how can i learn italy languageWebSep 14, 2024 · A549 cells were seeded in 96-well plates and cultured for 24 hours, then treated with varying concentrations of rhMG53 (0.05-100 μg/ml) or rhMG53 plus cisplatin (5 μM) for either 48 hours or 72 hours. Cells were detached by 0.25% Trypsin-EDTA solution, and their viability were quantified by flow cytometry (CytoFLEX S system, Beckman … how can i learn latinWebDec 1, 2024 · A549 cells, the human NSCLC cells with inherent cisplatin resistance, were used to investigate synergistic effect of sclareol with cisplatin in cell proliferation and migration as well as its regulatory mechanisms in expression of excision repair cross-complementation group 1 (ERCC1), a cisplatin resistance-associated molecule. how can i learn more about chatgptWebFigure 6: SRF231 Administration Enhances Survival in the A549 Lung Orthotopic Xenograft Model A549-Luc tumor cells were implanted orthotopically into the lungs of SCID beige mice. Ten days postimplant, animals were sorted based on BLI imaging and treated IP with 800 μg SRF231 or human IgG4 isotype control antibodies biw x 3. how many people die due to lack of healthcare